Quantitative proteomic analysis of the central amygdala in neuropathic pain model rats.

Pain and emotional distress have a reciprocal relation. The amygdala has been implicated in emotional processing. The central nucleus of amygdala (CeA) receives nociceptive information from the dorsal horn of spinal cord, and responsible for the central plasticity in chronic pain. Neuropathic pain is a type of severe chronic pain and can be strongly influenced by emotional components.

Plastic changes in CeA may play a key role in the development and/or maintenance of neuropathic pain. We studied the expression levels of proteins in CeA of spinal nerve transection (SNT) model rats.

Total tissue lysate proteins were separated by two dimensional-gel electrophoresis (2D-PAGE). Gels from different time points were compared using Progenesis SameSpot software, and the spots with Fold Change greater than 2 were excised for the protein identification by mass spectrometry.

We identified more than 50 cytosolic proteins as significantly altered in their expressions in CeA of SNT rats, and most of these changes have been validated at mRNA levels by qRT-PCR. We also identified more than 40 membrane proteins as notably up- or down-regulated in CeA of SNT model rats relative to a control using stable isotope dimethyl labeling nano-LC-MS/MS based proteomics and found that one of such protein, doublecortin, is specifically localized in the membrane fraction without changes in total amount of the protein.

Immunohistochemistry showed that doublecortin is expressed in processes in CeA of rats 7 and 21 days post SNT surgery, suggesting doublecorin is one of the proteins which may contribute to the plastic changes in CeA in the neuropathic pain model. These dysregulated proteins may play roles in reciprocal relationships between pain and psychological distress in the amygdala and contribute to central sensitization.

STA-21

2626-250
EUR 185

Isovaleryl-Phe-Nle-Sta-Ala-Sta-OH

H-5435.0001 1.0mg
EUR 357
Description: Sum Formula: C39H65N5O9; CAS# [98092-14-9]

Isovaleryl-Phe-Nle-Sta-Ala-Sta-OH

H-5435.0005 5.0mg
EUR 1336
Description: Sum Formula: C39H65N5O9; CAS# [98092-14-9]

Ganetespib (STA-9090)

A4385-10 10 mg
EUR 267
Description: Ganetespib (also known as STA-9090), 5-[2,4-dihydroxy-5-(1 methylethyl)phenyl]-2,4 dihydro-4-(1-methyl-1H indol-5 yl)-3H-1,2,4 triazole-3-one, is a potent small-molecule inhibitor of heat shock protein 90 (Hsp90), which binds to the ATP pocket in the N-terminus of Hsp90.

Ganetespib (STA-9090)

A4385-200 200 mg
EUR 1964
Description: Ganetespib (also known as STA-9090), 5-[2,4-dihydroxy-5-(1 methylethyl)phenyl]-2,4 dihydro-4-(1-methyl-1H indol-5 yl)-3H-1,2,4 triazole-3-one, is a potent small-molecule inhibitor of heat shock protein 90 (Hsp90), which binds to the ATP pocket in the N-terminus of Hsp90.

Ganetespib (STA-9090)

A4385-5 5 mg
EUR 206
Description: Ganetespib (also known as STA-9090), 5-[2,4-dihydroxy-5-(1 methylethyl)phenyl]-2,4 dihydro-4-(1-methyl-1H indol-5 yl)-3H-1,2,4 triazole-3-one, is a potent small-molecule inhibitor of heat shock protein 90 (Hsp90), which binds to the ATP pocket in the N-terminus of Hsp90.

Ganetespib (STA-9090)

A4385-5.1 10 mM (in 1mL DMSO)
EUR 224
Description: Ganetespib (also known as STA-9090), 5-[2,4-dihydroxy-5-(1 methylethyl)phenyl]-2,4 dihydro-4-(1-methyl-1H indol-5 yl)-3H-1,2,4 triazole-3-one, is a potent small-molecule inhibitor of heat shock protein 90 (Hsp90), which binds to the ATP pocket in the N-terminus of Hsp90.

Ganetespib (STA-9090)

A4385-50 50 mg
EUR 688
Description: Ganetespib (also known as STA-9090), 5-[2,4-dihydroxy-5-(1 methylethyl)phenyl]-2,4 dihydro-4-(1-methyl-1H indol-5 yl)-3H-1,2,4 triazole-3-one, is a potent small-molecule inhibitor of heat shock protein 90 (Hsp90), which binds to the ATP pocket in the N-terminus of Hsp90.

Ganetespib (STA-9090)

A4385-S Evaluation Sample
EUR 81
Description: Ganetespib (also known as STA-9090), 5-[2,4-dihydroxy-5-(1 methylethyl)phenyl]-2,4 dihydro-4-(1-methyl-1H indol-5 yl)-3H-1,2,4 triazole-3-one, is a potent small-molecule inhibitor of heat shock protein 90 (Hsp90), which binds to the ATP pocket in the N-terminus of Hsp90.

Elesclomol (STA-4783)

A4386-10 10 mg
EUR 311
Description: Elesclomol (also known as STA-4783), originally identified in a cell-based phenotypic screen for proapoptotic activity, is a novel small-molecule that potently induces apoptosis of cancer cells through the rapid generation of reactive oxygen species (ROS).

Elesclomol (STA-4783)

A4386-200 200 mg
EUR 2071
Description: Elesclomol (also known as STA-4783), originally identified in a cell-based phenotypic screen for proapoptotic activity, is a novel small-molecule that potently induces apoptosis of cancer cells through the rapid generation of reactive oxygen species (ROS).

Elesclomol (STA-4783)

A4386-5 5 mg
EUR 187
Description: Elesclomol (also known as STA-4783), originally identified in a cell-based phenotypic screen for proapoptotic activity, is a novel small-molecule that potently induces apoptosis of cancer cells through the rapid generation of reactive oxygen species (ROS).

Elesclomol (STA-4783)

A4386-5.1 10 mM (in 1mL DMSO)
EUR 200
Description: Elesclomol (also known as STA-4783), originally identified in a cell-based phenotypic screen for proapoptotic activity, is a novel small-molecule that potently induces apoptosis of cancer cells through the rapid generation of reactive oxygen species (ROS).

Elesclomol (STA-4783)

A4386-50 50 mg
EUR 843
Description: Elesclomol (also known as STA-4783), originally identified in a cell-based phenotypic screen for proapoptotic activity, is a novel small-molecule that potently induces apoptosis of cancer cells through the rapid generation of reactive oxygen species (ROS).

Elesclomol (STA-4783)

B1815-25
EUR 637

Elesclomol (STA-4783)

B1815-5
EUR 196

Ganetespib (STA-9090)

9459-25
EUR 588

Ganetespib (STA-9090)

9459-5
EUR 185

5-TAMRA [5-Carboxytetramethylrhodamine] *CAS 91809-66-4*

363 10 mg
EUR 115

Ac-Pepstatin [Ac-Val-Val-Sta-Ala-Sta (MW: 471.56)]

SP-86490-10 10mg
EUR 225

JKC 363

B5428-.5 500 ug
EUR 284

Isovaleryl-Val-Val-Sta-OEt

H-6680.0001 1.0mg
EUR 357
Description: Sum Formula: C25H47N3O6; CAS# [120849-36-7]

Isovaleryl-Val-Val-Sta-OEt

H-6680.0005 5.0mg
EUR 1336
Description: Sum Formula: C25H47N3O6; CAS# [120849-36-7]

AR (Ab-363) Antibody

CSB-PA082237-
EUR 335
Description: A polyclonal antibody against AR (Ab-363). Recognizes AR (Ab-363) from Human, Mouse. This antibody is Unconjugated. Tested in the following application: ELISA, WB;WB:1:500-1:3000

AR (Ab-363) Antibody

CSB-PA082237-100ul 100ul
EUR 316
Description: A polyclonal antibody against AR (Ab-363). Recognizes AR (Ab-363) from Human, Mouse. This antibody is Unconjugated. Tested in the following application: ELISA, WB;WB:1:500-1:3000

rno-miR-363 Primers

MP-r00199 150 ul / 10 uM
EUR 176

hsa-miR-363 Primers

MPH01486 150 ul / 10 uM
EUR 121

Kallikrein 4/EMSP1/KLK4

E21-363 10ug
EUR 343

Recombinant (E.Coli) Human Ubiquitin Conjugating Enzyme 9, His-tag

RP-363 10 ug
EUR 225

M-CSF R / CSF1R / CD115 Recombinant Protein

11-363 0.1 mg
EUR 595.25
Description: Colony stimulating factor 1 receptor (CSF1R) is also known as macrophage colony-stimulating factor receptor (M-CSFR), CD115 Cluster of Differentiation 115 (CD115), C-FMS, CSFR, FIM2, FMS, and is a member of the typeⅢ subfamily of receptor tyrosine kinases (RTKs). CSF1R is a receptor for a cytokine called colony stimulating factor 1, The protein encoded by the CSFR1 gene is the receptor for colony stimulating factor 1, a cytokine which controls the production, differentiation, and function of macrophages. This receptor mediates most, if not all, of the biological effects of this cytokine. Ligand binding activates CSFR1 through a process of oligomerization and transphosphorylation . Mutations in CSF1R are associated with chronic myelomonocytic leukemia and type M4 acute myeloblastic leukemia. Increased levels of CSF1R1 are found in microglia in Alzheimer's disease and after brain injuries. The increased receptor expression causes microglia to become more active. Both CSF1R, and its ligand colony stimulating factor 1 play an important role in the development of the mammary gland and may be involved in the process of mammary gland carcinogenesis.

NAPRTase Recombinant Protein

90-363 50 ug
EUR 626.75
Description: Human nicotinate phosphoribosyltransferase (NAPRTase) is localized in the cytoplasm and is involved in biological processes such as NAD biosynthetic and metabolic processes, nicotinamide metabolic process, nicotinate nucleotide salvage, response to oxidative stress and water-soluble vitamin metabolic process. It functions by catalyzing the conversion of nicotinic acid (NA) to NA mononucleotide (NaMN) and is essential for NA to increase cellular NAD levels and prevent oxidative stress of the cells. It is a crucial factor in the NAD+ biosynthesis pathway. Catalytic activity: Beta-nicotinate D-ribonucleotide + diphosphate = nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate.

Wnt Inhibitory Factor 1 Recombinant Protein

91-363 0.05 mg
EUR 464
Description: Wnt Inhibitory Factor 1 (WIF1) is a secreted protein, which binds WNT proteins and inhibits their activities. WNT proteins are extracellular signaling molecules involved in the control of embryonic development. WIF1 contains a WNT inhibitory factor (WIF) domain and 5 epidermal growth factor (EGF)-like domains. is found to be present in fish, amphibia and mammals. WIF1 is a recurrent target in human salivary gland oncogenesis.WIF1 may be involved in mesoderm segmentation. WIF1 is a tumor suppressor, specifically in nonfunctioning pituitary tumors.

IL-12 Recombinant Protein

92-363 0.05 mg
EUR 684.5
Description: IL-12 is involved in the differentiation of naive T cells into Th1 cells. It is known as a T cell-stimulating factor, which can stimulate the growth and function of T cells. It stimulates the production of interferon-gamma (IFN- gamma ) and tumor necrosis factor-alpha (TNF- alpha) from T cells and natural killer (NK) cells, and reduces IL-4 mediated suppression of IFN- gamma . T cells that produce IL-12 have a coreceptor, CD30, which is associated with IL-12 activity.IL-12 plays an important role in the activities of natural killer cells and T lymphocytes. IL-12 mediates enhancement of the cytotoxic activity of NK cells and CD8+ cytotoxic T lymphocytes.

Polyclonal RFFL Antibody (aa1-363)

APR02223G 0.05mg
EUR 484
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human RFFL (aa1-363). This antibody is tested and proven to work in the following applications:

Androgen Receptor (Ab-363) Antibody

33255-100ul 100ul
EUR 252

Androgen Receptor (Ab-363) Antibody

33255-50ul 50ul
EUR 187

hsa-miR-363 miRNA Inhibitor

MIH01956 2 x 5.0 nmol
EUR 176

rno??miR-363 miRNA Inhibitor

MIR01523 2 x 5.0 nmol
EUR 176

rno??miR-363 miRNA Antagomir

MNR01523 2 x 5.0 nmol
EUR 329

hsa-miR-363-3p Primers

MPH02515 150 ul / 10 uM
EUR 121

hsa-miR-363-5p Primers

MPH02516 150 ul / 10 uM
EUR 121

mmu-miR-363-3p Primers

MPM00441 150 ul / 10 uM
EUR 121

mmu-miR-363-5p Primers

MPM00442 150 ul / 10 uM
EUR 121

rno-miR-363-3p Primers

MPR00650 150 ul / 10 uM
EUR 176

rno-miR-363-5p Primers

MPR00651 150 ul / 10 uM
EUR 176

hsa-miR-363 miRNA Antagomir

MNH01956 2 x 5.0 nmol
EUR 329

pCMV-SPORT6-PATL1(363-2313bp)

PVT14331 2 ug
EUR 495

for Heat Stable Enterotoxin a (STa)ELISA kit

SEO805Ge-10x96wellstestplate 10x96-wells test plate
EUR 5386
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of for Heat Stable Enterotoxin a (STa) in Biological agents.

for Heat Stable Enterotoxin a (STa)ELISA kit

SEO805Ge-1x48wellstestplate 1x48-wells test plate
EUR 531.2
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of for Heat Stable Enterotoxin a (STa) in Biological agents.

for Heat Stable Enterotoxin a (STa)ELISA kit

SEO805Ge-1x96wellstestplate 1x96-wells test plate
EUR 716
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of for Heat Stable Enterotoxin a (STa) in Biological agents.

for Heat Stable Enterotoxin a (STa)ELISA kit

SEO805Ge-5x96wellstestplate 5x96-wells test plate
EUR 2922
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of for Heat Stable Enterotoxin a (STa) in Biological agents.

ELISA Kit for Heat Stable Enterotoxin a (STa)

4-SEO805Ge
  • EUR 5437.00
  • EUR 2873.00
  • EUR 717.00
  • 10 plates of 96 wells
  • 5 plates of 96 wells
  • 1 plate of 96 wells
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Heat Stable Enterotoxin a (STa) in samples from Biological agents with no significant corss-reactivity with analogues from other species.

Androgen Receptor (Ab-363) Conjugated Antibody

C33255 100ul
EUR 397

hsa-miR-363-3p miRNA Inhibitor

MIH01957 2 x 5.0 nmol
EUR 176

hsa-miR-363-5p miRNA Inhibitor

MIH01958 2 x 5.0 nmol
EUR 176

mmu-miR-363-3p miRNA Inhibitor

MIM01965 2 x 5.0 nmol
EUR 176

mmu-miR-363-5p miRNA Inhibitor

MIM01966 2 x 5.0 nmol
EUR 176

rno-miR-363-3p miRNA Inhibitor

MIR01524 2 x 5.0 nmol
EUR 176

rno-miR-363-5p miRNA Inhibitor

MIR01525 2 x 5.0 nmol
EUR 176

mmu-miR-363-3p miRNA Antagomir

MNM01965 2 x 5.0 nmol
EUR 329

mmu-miR-363-5p miRNA Antagomir

MNM01966 2 x 5.0 nmol
EUR 329

rno-miR-363-3p miRNA Antagomir

MNR01524 2 x 5.0 nmol
EUR 329

rno-miR-363-5p miRNA Antagomir

MNR01525 2 x 5.0 nmol
EUR 329

hsa-miR-363-3p miRNA Antagomir

MNH01957 2 x 5.0 nmol
EUR 329

hsa-miR-363-5p miRNA Antagomir

MNH01958 2 x 5.0 nmol
EUR 329

Porcine Signal transducer and activator of transcription 5B, STA

ELI-39535p 96 Tests
EUR 928

Porcine Signal transducer and activator of transcription 5A, STA

ELI-05635p 96 Tests
EUR 928

BOC-Statine [BOC-Sta(3S,4S)-OH] *CAS 58521-49-6*

5100 1 g
EUR 480

BOC-Statine [BOC-Sta(3S,4S)-OH] *CAS 58521-49-6*

5101 10 g
EUR 2220

FMOC-Statine [FMOC-Sta(3S,4S)-OH] *CAS 158257-40-0*

5106 1 g
EUR 480

FMOC-Statine [FMOC-Sta(3S,4S)-OH] *CAS 158257-40-0*

5107 10 g
EUR 2616

Recombinant Plasmodium Knowlesi CSP Protein (aa 20-363)

VAng-Wyb7804-1mgEcoli 1 mg (E. coli)
EUR 4380
Description: Plasmodium Knowlesi (strain H) Circumsporozoite protein, recombinant protein.

Recombinant Plasmodium Knowlesi CSP Protein (aa 20-363)

VAng-Wyb7804-500gEcoli 500 µg (E. coli)
EUR 3103
Description: Plasmodium Knowlesi (strain H) Circumsporozoite protein, recombinant protein.

Recombinant Plasmodium Knowlesi CSP Protein (aa 20-363)

VAng-Wyb7804-50gEcoli 50 µg (E. coli)
EUR 2126
Description: Plasmodium Knowlesi (strain H) Circumsporozoite protein, recombinant protein.

Recombinant Mycobacterium Tuberculosis galK Protein (aa 1-363)

VAng-Yyj0054-50gEcoli 50 µg (E. coli)
EUR 2179
Description: Mycobacterium Tuberculosis Galactokinase (galK), recombinant protein.

Recombinant Mycobacterium Tuberculosis ctaC Protein (aa 42-363)

VAng-Yyj0431-inquire inquire Ask for price
Description: Mycobacterium Tuberculosis Cytochrome c oxidase subunit 2 (ctaC), recombinant protein.

Recombinant Mycobacterium Marinum mnmA Protein (aa 1-363)

VAng-Yyj4454-1mgEcoli 1 mg (E. coli)
EUR 4504
Description: Mycobacterium Marinum (strain ATCC BAA-535 / M) tRNA-specific 2-thiouridylase mnmA (mnmA), recombinant protein.

Recombinant Mycobacterium Marinum mnmA Protein (aa 1-363)

VAng-Yyj4454-500gEcoli 500 µg (E. coli)
EUR 3184
Description: Mycobacterium Marinum (strain ATCC BAA-535 / M) tRNA-specific 2-thiouridylase mnmA (mnmA), recombinant protein.

Recombinant Mycobacterium Marinum mnmA Protein (aa 1-363)

VAng-Yyj4454-50gEcoli 50 µg (E. coli)
EUR 2181
Description: Mycobacterium Marinum (strain ATCC BAA-535 / M) tRNA-specific 2-thiouridylase mnmA (mnmA), recombinant protein.

Recombinant Mycobacterium Smegmatis murB Protein (aa 1-363)

VAng-Yyj4748-1mgEcoli 1 mg (E. coli)
EUR 4504
Description: Mycobacterium Smegmatis (strain ATCC 700084 / mc(2)155) UDP-N-acetylenolpyruvoylglucosamine reductase (murB), recombinant protein.

Recombinant Mycobacterium Smegmatis murB Protein (aa 1-363)

VAng-Yyj4748-500gEcoli 500 µg (E. coli)
EUR 3184
Description: Mycobacterium Smegmatis (strain ATCC 700084 / mc(2)155) UDP-N-acetylenolpyruvoylglucosamine reductase (murB), recombinant protein.

Recombinant Mycobacterium Smegmatis murB Protein (aa 1-363)

VAng-Yyj4748-50gEcoli 50 µg (E. coli)
EUR 2181
Description: Mycobacterium Smegmatis (strain ATCC 700084 / mc(2)155) UDP-N-acetylenolpyruvoylglucosamine reductase (murB), recombinant protein.

Recombinant Mycobacterium Smegmatis ino1 Protein (aa 1-363)

VAng-Yyj4923-1mgEcoli 1 mg (E. coli)
EUR 4504
Description: Mycobacterium Smegmatis (strain ATCC 700084 / mc(2)155) Inositol-3-phosphate synthase (ino1), recombinant protein.

Recombinant Mycobacterium Smegmatis ino1 Protein (aa 1-363)

VAng-Yyj4923-500gEcoli 500 µg (E. coli)
EUR 3184
Description: Mycobacterium Smegmatis (strain ATCC 700084 / mc(2)155) Inositol-3-phosphate synthase (ino1), recombinant protein.

Recombinant Mycobacterium Smegmatis ino1 Protein (aa 1-363)

VAng-Yyj4923-50gEcoli 50 µg (E. coli)
EUR 2181
Description: Mycobacterium Smegmatis (strain ATCC 700084 / mc(2)155) Inositol-3-phosphate synthase (ino1), recombinant protein.

Recombinant Schizosaccharomyces Pombe wtf4 Protein (aa 1-363)

VAng-Yyj6596-inquire inquire Ask for price
Description: Schizosaccharomyces Pombe (strain 972 / ATCC 24843) (Fission yeast) Uncharacterized protein wtf4 (wtf4), recombinant protein.

Recombinant Plasmodium Falciparum MSA2 Protein (aa 1-363)

VAng-Wyb6580-500g 500 µg
EUR 1205
Description: Plasmodium Falciparum merozoite surface antigen 2, recombinant protein.

Recombinant Mycobacterium Leprae pknA Protein (aa 363-437)

VAng-Yyj2255-500gEcoli 500 µg (E. coli)
EUR 2261
Description: Mycobacterium Leprae Probable serine/threonine-protein kinase pknA (pknA), recombinant protein.

Recombinant Mycobacterium Bovis galK Protein (aa 1-363)

VAng-Yyj2961-1mgEcoli 1 mg (E. coli)
EUR 4504
Description: Mycobacterium Bovis Galactokinase (galK), recombinant protein.

Recombinant Mycobacterium Bovis galK Protein (aa 1-363)

VAng-Yyj2961-500gEcoli 500 µg (E. coli)
EUR 3184
Description: Mycobacterium Bovis Galactokinase (galK), recombinant protein.

Recombinant Mycobacterium Bovis galK Protein (aa 1-363)

VAng-Yyj2961-50gEcoli 50 µg (E. coli)
EUR 2181
Description: Mycobacterium Bovis Galactokinase (galK), recombinant protein.

Recombinant Mycobacterium Ulcerans mnmA Protein (aa 1-363)

VAng-Yyj3727-1mgEcoli 1 mg (E. coli)
EUR 4504
Description: Mycobacterium Ulcerans (strain Agy99) tRNA-specific 2-thiouridylase mnmA (mnmA), recombinant protein.

Recombinant Mycobacterium Ulcerans mnmA Protein (aa 1-363)

VAng-Yyj3727-500gEcoli 500 µg (E. coli)
EUR 3184
Description: Mycobacterium Ulcerans (strain Agy99) tRNA-specific 2-thiouridylase mnmA (mnmA), recombinant protein.

Recombinant Mycobacterium Ulcerans mnmA Protein (aa 1-363)

VAng-Yyj3727-50gEcoli 50 µg (E. coli)
EUR 2181
Description: Mycobacterium Ulcerans (strain Agy99) tRNA-specific 2-thiouridylase mnmA (mnmA), recombinant protein.

Recombinant Haemophilus Influenzae ompP2 Protein (aa 21-363)

VAng-Lsx03579-1mgEcoli 1 mg (E. coli)
EUR 4380
Description: Haemophilus Influenzae Outer membrane protein P2 (aa 21-363), recombinant protein.

Recombinant Haemophilus Influenzae ompP2 Protein (aa 21-363)

VAng-Lsx03579-500gEcoli 500 µg (E. coli)
EUR 3103
Description: Haemophilus Influenzae Outer membrane protein P2 (aa 21-363), recombinant protein.